Penambatan molekul senyawa turunan orizanol terhadap enzim 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reduktase

  • Syaikhul Aziz Program Studi Farmasi, Institut Teknologi Sumatera, Lampung Selatan, Indonesia, 35365
  • Nur Adliani Program Studi Farmasi, Institut Teknologi Sumatera, Lampung Selatan, Indonesia, 35365
  • Sukrasno Sukrasno Kelompok Keilmuan Biologi Farmasi, Sekolah Farmasi, Institut Teknologi Bandung, 40132, Indonesia

Abstract

Oryzanol has been reported to reduce serum total cholesterol (hypolipidemic agent) by inhibiting HMG-CoA reductase, an enzyme responsible for the metabolic pathway that produces cholesterol and isoprenoid. The purpose of this experiment is to determine the inhibition activity of oryzanol derivatives on HMG-CoA reductase by molecular docking. Four structure of oryzanol derivatives, Lanosteryl-ferulate, Brassicasteryl-ferulate, Lupeol-ferulate, and Cholesteryl-ferulate were used as ligands for molecular docking. The HMG-CoA reductase structure was obtained from protein data bank and the study was performed using AutoDock Tools as a molecular docking software. All oryzanol derivatives show binding affinity against HMG-CoA reductase. Lupeol-ferulate was predicted to be the best inhibitory activity against HMG-CoA reductase because of molecular docking.

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Published
2020-06-15
How to Cite
AZIZ, Syaikhul; ADLIANI, Nur; SUKRASNO, Sukrasno. Penambatan molekul senyawa turunan orizanol terhadap enzim 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reduktase. Journal of Science and Applicative Technology, [S.l.], v. 4, n. 1, p. 43-48, june 2020. ISSN 2581-0545. Available at: <https://journal.itera.ac.id/index.php/jsat/article/view/191>. Date accessed: 27 sep. 2020. doi: https://doi.org/10.35472/jsat.v4i1.191.