UJI AKTIVITAS EKSTRAK BUNGA KECOMBRANG (Etlingera elatior Jack) SEBAGAI HIPOLIPIDEMIA PADA TIKUS WISTAR OBESITAS

  • Sri Wardani Program Studi Kimia, Fakultas Matematika dan ilmu Pengetahuan Alam, Universitas Udayana, Bali, Indonesia
  • Ni Wayan Bogoriani Program Studi Kimia, Fakultas Matematika dan ilmu Pengetahuan Alam, Universitas Udayana, Bali, Indonesia
  • Ni Luh Rustini Program Studi Kimia, Fakultas Matematika dan ilmu Pengetahuan Alam, Universitas Udayana, Bali, Indonesia
DOI: https://doi.org/10.35472/jsat.v6i2.1000

Abstract

Kecombrang (Etlingera elatior Jack) is a plant that has potential for hypolipidemia. Kecombrang has secondary metabolites consisting of tannins, saponins, alkaloids, steroids, terpenoids, phenolics, and flavonoids. The purpose of this study was to determine the hypolipidemic activity of kecombrang flower methanol extract in obesed Wistar rats fed a high-fat diet. The test animals used in this study were 18 female white rats aged two months,  weight of ± 150 grams. The test animals were divided into three groups, namely normal control (only given standard feed), high-fat control (obesed rats with high-fat diet), and flower treatment group (obesed rats with a high-fat diet + flower methanol extract 100 mg/kgBW) orally for 30 days. The results showed that kecombrang flowers reduced total cholesterol levels by 55.5%, triglycerides (TG) by 57.4%, LDL by 76.73%, and increased HDL by 42.96%. The kecombrang flower has the potential for hypolipidemia which is characterized by a decrease in total cholesterol, TG, LDL, and can increase HDL levels in obese  rats significantly (p<0.05).

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Author Biographies

Sri Wardani, Program Studi Kimia, Fakultas Matematika dan ilmu Pengetahuan Alam, Universitas Udayana, Bali, Indonesia

Program Studi Kimia, Fakultas Matematika dan ilmu Pengetahuan Alam, Universitas Udayana, Bali, Indonesia

Ni Wayan Bogoriani, Program Studi Kimia, Fakultas Matematika dan ilmu Pengetahuan Alam, Universitas Udayana, Bali, Indonesia

Program Studi Kimia, Fakultas Matematika dan ilmu Pengetahuan Alam, Universitas Udayana, Bali, Indonesia

Ni Luh Rustini, Program Studi Kimia, Fakultas Matematika dan ilmu Pengetahuan Alam, Universitas Udayana, Bali, Indonesia

Program Studi Kimia, Fakultas Matematika dan ilmu Pengetahuan Alam, Universitas Udayana, Bali, Indonesia

References

[1]Artha, C., Mustika, A. and Sulistyawati, S. W., “Pengaruh Ekstrak Daun Singawalang terhadap Kadar LDL Tikus Putih Jantan Hiperkolesterolemia”,J.Kedokteran Indonesia.Vol.5. 2017
[2]Bogoriani, NW., Ariati, NK., Pratiwi, IGAPE.,“ Potency of Balinese Kecombrang (Etlingera elatior Jack.) Extract As Antioksidant Against The Activity of Superoxide Dismutase (SOD), Glutathione (GSH) and Fatty Liver in Obese Rats”,Biomedical & Pharmacology Journal. Vol.15(1), pp.337-244. 2022
[3]Bogoriani, NW., Laksmiwati, AAIM., Putra, AAB., Heltyani, WE., Lestari, KDP., Mahayani, PAE.“Saponins Role Of Bali Andong Leaf As Antiobesity In Rats”,International Journal of Pharmaceutical research. Vol.11 (2), pp.382-387. 2019
[4]Dheer, R. & Bhatnagar, P., “A study of the Antidiabetic Activity of Barleria Prionitis Linn”, Indian Journal of Pharmacology. Vol.42(2), pp.70-73. 2010
[5]Bogoriani,NW., Suaniti, NM., Bawa-Putra, AA., Lestari, KDP., Heltyani, W. “ The Effect of Cordyline terminalis’s Leaf Extract on Lipid Profile, Obesity and Liver Function in Obese induced Rats”, Systemtic Reviews in Pharmacy. Vol. 11 (11), pp. 1080-1086. 2020
[6]Kementerian Kesehatan Republik Indonesia, Riset Kesehatan Dasar 2018. Jakarta: Kementerian Kesehatan Republik Indonesia, 2018
[7]Nuralifah, N., Armadany FI., Parawansah,“Uji Aktivitas Antibakteri Sediaan Krim Anti Jerawat Ekstrak Etanol Terpurifikasi Daun Sirih (Piper betle L.) dengan Basis Vanishing Cream Terhadap Propionibacterium acne”,J.Pharmauho. vol.4 (2). 2020
[8]Prahastuti, S.,“Konsumsi Fruktosa Berlebihan dapat Berdampak Buruk Bagi Kesehatan Manusia”,J.Kesehatan Masyarakat. Vol.10, pp.173-189. 2011
[9]Robinson, T.,High Plant Organic Content. Edisi VI. Bandung: ITB, 1995
[10]Tortora, Gerald J., dan Derrickson, Bryan H.,Principles of Anatomy and Physiology. USA:Biological Science Textbooks, Inc, 2012
[11]WHO.,Health for the World’s Adolescents: A Second Chance in the Second Decade. Geneva: World Health Organization Departemen of Noncommunicable disease surveillance, 2014
[12]Witosari, N., Nurmasari&Widyastuti,“Pengaruh Pemberian Jus Daun Ubi Jalar (Ipomoea batatas (L) Lam) terhadap Kadar Kolesterol Total Tikus Wistar Jintan (Rattus norvegicus) yang diberi Pakan Tinggi lemak”,J.Peternakan. vol.3(4), pp.638-646. 2015
[13]Bogoriani, NW., Bawa-Putra, AA., Wahjuni, S., Heltyani, W., Dewi, NPPM., Sadin, VYK. The Effect of Andong (Cordyline terminalis) leave, one of the traditional plants in Bali as antioxidant and antibacterial. IOP Conf. Series: Earth and Environmental Science. 724 (012018) 2021
Published
2022-12-29
How to Cite
WARDANI, Sri; BOGORIANI, Ni Wayan; RUSTINI, Ni Luh. UJI AKTIVITAS EKSTRAK BUNGA KECOMBRANG (Etlingera elatior Jack) SEBAGAI HIPOLIPIDEMIA PADA TIKUS WISTAR OBESITAS. Journal of Science and Applicative Technology, [S.l.], v. 6, n. 2, p. 118-123, dec. 2022. ISSN 2581-0545. Available at: <https://journal.itera.ac.id/index.php/jsat/article/view/1000>. Date accessed: 25 apr. 2024. doi: https://doi.org/10.35472/jsat.v6i2.1000.
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Vol 6 No 2 (2022): Journal of Science and Applicative Technology December Chapter
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Articles
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